What is Chondrocalcinosis?



calcium pyrophosphate dihydrate disease (CPDD)


is an acute form of arthritis and a rheumatoid disorder. Crystals of calcium pyrophosphate dihydrate get deposited in the joints and the connective tissues which lead to inflammation of the joints. The knee joints are the most affected due to the pyrophosphate crystals and more than one joint at once can get inflamed due to this disorder.

Chondrocalcinosis and Gout/Pseudogout:

Gout is also a form of arthritis that is caused due to the increase in blood uric acid. The excess uric acid in the blood develops into urate crystals and gets deposited in joint spaces which leads to redness and inflammation of the joints. Pseudogout is more or less similar to gout.

  • In CPPD, the hyaline cartilage gets calcified which can be identified through radiography.
  • After the knee joints, it is the wrist joints and the hip joints that are most vulnerable to CPDD.


As already mentioned, CPPD can affect multiple joints, thus making it a polyarticular form of arthritis. As a matter of fact, it actually begins as a monoarticular form of arthritis affecting articular tissues.

  • The exact cause of the disorder is rather unknown, but some scientists have classified a link between the gene


    and the disorder which leads to crystal related inflammatory reactions.

  • While another study established a relation between the disorder and the chromosome



Signs and Symptoms:

The following are the general symptoms of the disorder-

  • joint swelling
  • joint pain
  • joint stiffness
  • People who suffer from the disorder have an increased count of WBC.
  • Upon microscopic examination, one can find the presence of rhombus shaped crystals in the joint fluid.
  • People suffering from calcium pyrophosphate disorder also have a chance of developing osteoarthritis or Wilson’s disease.
  • People whose wrists are affected can develop carpal tunnel syndrome.




is not causing any pain, then it is suggested not to to use any medication as there can be a threat of organ damage. Otherwise, NSAIDs, corticosteroid injections and colchicine are recommended for acute attacks.

Leave a reply

Your email address will not be published. Required fields are marked *